Arvind9 wrote: In India only 12% of the population is vaccinated in 130 days the ceo of thr firm that supplied vaccines to the government has left India because of too much pressure from the government he is in London with his family thats why many people are left with only one dose because vaccines are not available thats why SPUTNIK V has been imported from Russia but is it effective enough to protect against Indian variants thats the big question everything is mismanaged according to a New York times report Narendra Modi is one of the five world leaders who are worst in handling the pandemic
Sputnik V is an adenoviral based vaccine, it uses a proven method, of course maybe not as promising as mRNA, but still these vaccines offer very good protection against severe forms of the infection. As far as variants, obviously they reduce to some extent the effectiveness of vaccines, what would be the most concerning is major mutations. In a variant only partial modification to the virus is present, in these cases to the spike protein to make them adhere more easily to ACE2 receptors, so they are much more infectious - but in all variants you still have commonalities - it should in theory be enough for your body to still neutralise the virus, albeit, it may be more challenging for your body - given the vaccines very high efficacy against the original strain, this means that even with a variant reducing efficacy of vaccines, your protection would still be high enough, you would still, in theory have enough antibodies / protection left to deal with the variant. The issue is, what if a the virus mutations make significant changes, then I guess it would significantly reduce the vaccine efficacy - so eventually they will need to make new vaccines for new variants just like they do with the Flu shot every year.
Pfizer and Moderna are mRNA, with these type of vaccines, their makers can create a new version within only weeks. It would take far longer for the adenovirus - MUCH longer, because with mRNA, it is your own body's cells that build the actual protein spikes that will trigger your immune system to build antibodies.....so instead of the big pharmas manufacturing the key vaccine, they are manufacturing the CODE to inject into your cells (temporary code that fades with time) that let your body be the factory.
As far as India, wow it is such a low figure of vaccination coverage that is such a shame. For now vaccines can still offer good protection against variants - BUT I do not think it will be the case forever - once the mutations evolve into a significantly different version compared to the original one, then new vaccines will be required to prime your body for better protection. I guess for mRNA vaccines, they still offer good enough protection from variants,. including Indian variant, even with a reduced efficacy. As far as the adenoviral vaccines, their efficacy might be more reduced, by ho much nobody knows for sure, but the protection should still be above 50% - if you look at the Flu vaccine it is between 40%-60%, so I'd say the COVID19 vaccines are very much effective in comparison, even with the variants.
How did China avoid those f****** variants ? By actually following the guidelines and strict rules........ If the idiot politicians in the rest of the world did not take this pandemic seriously and allowed the virus to go out of control, they are to blame..........and people who use as excuse that some countries have dense populations making it impossible to control, that is complete rubbish - Look at China's population, look at how long it took them to end their local outbreaks...........and when I see countries like the US with less than 50% vaccine coverage, touting victory and lifting all restrictions, I really worry - If Canada and US doesn't wake the f*** up soon, I would not be surprised if North America might live pretty much the same scenario as seen in India, or Brazil......and so all this vaccine business will have been for nothing - and after those 2 painful doses of vaccine I sure ain't taking anymore g******** vaccine shots, unless I can see a light at the end of this long dark tunnel - Right now the Holocaust of COVID19 is not over.................countries acting like it is over are totally IGNORANT.
India should be VERY concerned - the main reason for variants is the continued community spread - the situation won't get better anytime soon, and if the shitty situation in India is allowed to continue, new variants will emerge, right now vaccines are effective, but eventually they won't be ........
IN any case with all vaccines, nobody knows the long term effects, will we grow a 3rd arm, grow horns, grow beards, grow private parts, change genders, start speaking Latin, become Autistic (yes some claim this is a risk), nobody knows, in 5-10 years we'll know for sure, let's hope we don't turn into Zombies, that's all.....